DNA copy-number measurement of genome replication dynamics by high-throughput sequencing: the sort-seq, sync-seq and MFA-seq family.

Genome replication follows a defined temporal programme that can change during cellular differentiation and disease onset. DNA replication results in an increase in DNA copy number that can be measured by high-throughput sequencing. Here we present a protocol to determine genome replication dynamics...

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Detalhes bibliográficos
Principais autores: Batrakou, DG, Müller, CA, Wilson, RHC, Nieduszynski, CA
Formato: Journal article
Idioma:English
Publicado em: Nature Research 2020