Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice

The Finnish variant Late Infantile Neuronal Ceroid Lipofuscinosis (vLINCLFin), also known as CLN5 disease, is caused by mutations in the CLN5 gene. Cln5 is strongly expressed in the developing brain and expression continues into adulthood. CLN5, a protein of unknown function, is implicated in neurod...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Singh, Y, Leinonen, H, Fazaludeen, F, Jaronen, M, Guest, D, Buckley, N, Byts, N, Oksa, P, Jalkanen, K, Iqbal, I, Huuskonen, M, Savchenko, E, Keksa-Goldsteine, V, Chew, S, Myllyharju, J, Tanila, H, Ooi, L, Koistinaho, J, Kanninen, K, Malm, T
Format: Journal article
Sprache:English
Veröffentlicht: Oxford University Press 2019