Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.

MLL fusion proteins are oncogenic transcription factors that are associated with aggressive lymphoid and myeloid leukemias. We constructed an inducible MLL fusion, MLL-ENL-ERtm, that rendered the transcriptional and transforming properties of MLL-ENL strictly dependent on the presence of 4-hydroxy-t...

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Detalles Bibliográficos
Autores principales: Zeisig, B, Milne, T, García-Cuéllar, M, Schreiner, S, Martin, M, Fuchs, U, Borkhardt, A, Chanda, S, Walker, J, Soden, R, Hess, J, Slany, R
Formato: Journal article
Lenguaje:English
Publicado: 2004