Assessing the role of ADAM10 in Trastuzumab treatment and resistance

Assessing the role of ADAM10 in Trastuzumab treatment and resistance

<p>Overexpression of the HER2 receptor occurs in about 15-20% of all breast cancers and is correlated with poor prognosis. Trastuzumab (Herceptin®), a monoclonal antibody targeting HER2, was shown to prolong survival of these patients. However, primary or acquired resistance remains a drawback...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Feldinger, K
Awduron Eraill:	Kong, A
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2012
Pynciau:	Cell Biology (see also Plant sciences) Oncology Biology

Eitemau Tebyg

Functional organisation of the Hrd1 ubiquitin ligase complex and its role in ERAD
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The role and regulation of Asterless in the centrosome cycle
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Cyhoeddwyd: (2014)

Characterisation of AEBP2: a polycomb repressive complex 2 component
gan: Grijzenhout, A
Cyhoeddwyd: (2013)

Cell stress response and hypoxia in breast cancer
gan: Milani, M, et al.
Cyhoeddwyd: (2011)

Nitric oxide: a chemical effector of pathogenesis in magnaporthe oryzae
gan: Johnson, J
Cyhoeddwyd: (2011)

The role of protein kinase C in platelet activation
gan: Unsworth, AJ
Cyhoeddwyd: (2012)

The role of Adaptor Protein 3 in cytotoxic T lymphocytes
gan: Wenham, M
Cyhoeddwyd: (2009)

Regulation of E2F-1 by methylation and NEDDylation
gan: Loftus, S, et al.
Cyhoeddwyd: (2012)

Heterogeneity of tumour response to hypoxia: carbonic anhydrase IX induction defines a subpopulation of hypoxic cells with stem cell properties and drug resistance
gan: Ledaki, I
Cyhoeddwyd: (2013)

Functions of conserved centriole proteins in African trypanosomes
gan: Scheumann, N
Cyhoeddwyd: (2012)

Towards understanding the mechanism of cohesin loading
gan: Dixon, SE
Cyhoeddwyd: (2013)

E2F7: a member of the E2F family with a novel mechanism of transcriptional repression
gan: Kesoglidou, PX
Cyhoeddwyd: (2012)

Factors contributing to chondroplasia in degenerate rotator cuff disease
gan: Cornell, HR
Cyhoeddwyd: (2011)

Targeting cell adhesion as a method of sensitising metastatic tumour cells to TRAIL-induced apoptosis
gan: Phipps, L
Cyhoeddwyd: (2011)

Determining the mechanism of pathogenesis of mucolipidosis type IV and related lysosomal storage disorders for development of novel therapies
gan: Peterneva, K
Cyhoeddwyd: (2014)

Investigating the function of Drosophila MAPs Msd1 and dTD-60 in mitotic spindle assembly
gan: Duncan, T
Cyhoeddwyd: (2011)

Design, implementation and experimental validation of a network-based model to predict mitotic microtubule regulating proteins
gan: Khan, FF
Cyhoeddwyd: (2013)

Deconstructing the trypanosome cytoskeleton: from structures to functions via components and complexes.
gan: Portman, N
Cyhoeddwyd: (2011)

Structure-function studies of fibronectin domains in the human endometrium
gan: Mok, M, et al.
Cyhoeddwyd: (2008)

Syncrip regulates mRNA localisation and translation at the drosophila neuromuscular junction
gan: Halstead, J
Cyhoeddwyd: (2013)

Studies on HIF hydroxylases
gan: Webb, J
Cyhoeddwyd: (2008)

Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF
gan: Knowles, H, et al.
Cyhoeddwyd: (2008)

Functional analysis of cancer/testis antigens in human cancer
gan: Pagotto, A
Cyhoeddwyd: (2013)

Human orthologues of Saccharomyces cerevisiae Trf4/5 non-canonical poly(A) polymerases
gan: Gibson, K
Cyhoeddwyd: (2011)

The influence of BRCA1's ubiquitin ligase activity on cell motility
gan: Sengupta, S
Cyhoeddwyd: (2014)

Regulation and reproductive functions of membrane-bound vesicles secreted by the Drosophila male accessory gland
gan: Corrigan, L
Cyhoeddwyd: (2014)

The evolution of eukaryotic cilia
gan: Hodges, M, et al.
Cyhoeddwyd: (2011)

The role of autophagy in CD8+ T cell immunity
gan: Puleston, D, et al.
Cyhoeddwyd: (2015)

Wac: a new Augmin subunit required for chromosome alignment but not for acentrosomal microtubule assembly in female meiosis
gan: Meireles, A, et al.
Cyhoeddwyd: (2009)

The relation between multilocus population genetics and social evolution theory
gan: Gardner, A, et al.
Cyhoeddwyd: (2007)

Cellular models for characterisation of MINA53, a 2-oxoglutarate-dependent dioxygenase
gan: Zayer, A
Cyhoeddwyd: (2012)

Vertex model approaches to epithelial tissues in developmental systems
gan: Smith, A
Cyhoeddwyd: (2012)

Identification and characterisation of homologous recombination genes in Schizosaccharomyces pombe
gan: Moss, J
Cyhoeddwyd: (2011)

Mucosal associated invariant T cells and related CD161 expressing T lymphocytes
gan: Fergusson, J, et al.
Cyhoeddwyd: (2015)

Segmentation of cell clumps for quantitative analysis
gan: Li, S
Cyhoeddwyd: (2010)

Expression of two-pore channels in mammalian primary cells and tissues, and their role in adipose tissue formation and function
gan: Tunn, R
Cyhoeddwyd: (2012)

Elucidating the pathway of centrosome formation
gan: Costa Vicente, C
Cyhoeddwyd: (2013)

Automated segmentation and alignment of mitotic nuclei for Kymograph visualisation
gan: Li, S, et al.
Cyhoeddwyd: (2011)

The role of p53 in hypoxia-induced apoptosis
gan: Poole, R
Cyhoeddwyd: (2010)

Effect of CTCF and Cohesin on the dynamics of RNA polymerase II transcription and coupled pre-messenger RNA processing
gan: Liska, O
Cyhoeddwyd: (2013)