TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors.

Aggrecanases are considered to play a key role in the destruction of articular cartilage during the progression of arthritis. Here we report that the N-terminal inhibitory domain of tissue inhibitor of metalloproteinases 3 (N-TIMP-3), but not TIMP-1 or TIMP-2, inhibits glycosaminoglycan release from...

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Bibliografski detalji
Glavni autori: Gendron, C, Kashiwagi, M, Hughes, C, Caterson, B, Nagase, H
Format: Journal article
Jezik:English
Izdano: 2003