Bifunctional iminophosphorane catalyzed amide enolization for enantioselective cyclohexadienone desymmetrization.

Bifunctional iminophosphorane catalyzed amide enolization for enantioselective cyclohexadienone desymmetrization.

The organocatalytic enolization of 2-arylacetamides, followed by an enantioselective intramolecular conjugate addition to tethered 2,5-cyclohexadienones, yielding 3D fused N-heterocycles, is described. The transformation represents the first strong activating group-free activation of carboxamides vi...

Полное описание

Библиографические подробности
Главные авторы:	Poh, CYX, Rozsar, D, Yang, J, Christensen, KE, Dixon, DJ
Формат:	Journal article
Язык:	English
Опубликовано:	Wiley 2023

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