JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.

JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.

Recent studies strongly suggest an active involvement of the c-Jun N-terminal kinase (JNK) signaling pathway in tumor necrosis factor (TNF)-induced apoptosis. The direct evidence for the role of JNK and its isoforms has been missing and the mechanism of how JNK actually could facilitate this process...

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Bibliographische Detailangaben
Hauptverfasser:	Dietrich, N, Thastrup, J, Holmberg, C, Gyrd-Hansen, M, Fehrenbacher, N, Lademann, U, Lerdrup, M, Herdegen, T, Jäättelä, M, Kallunki, T
Format:	Journal article
Sprache:	English
Veröffentlicht:	2004

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