JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.
Recent studies strongly suggest an active involvement of the c-Jun N-terminal kinase (JNK) signaling pathway in tumor necrosis factor (TNF)-induced apoptosis. The direct evidence for the role of JNK and its isoforms has been missing and the mechanism of how JNK actually could facilitate this process...
Հիմնական հեղինակներ: | Dietrich, N, Thastrup, J, Holmberg, C, Gyrd-Hansen, M, Fehrenbacher, N, Lademann, U, Lerdrup, M, Herdegen, T, Jäättelä, M, Kallunki, T |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
2004
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