HLA-B27
Possession of the human leukocyte antigen (HLA) class I molecule B27 is strongly associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown. Two broad theories most likely explain the role of HLA-B27 in AS pathogenesis. The first is based on the natural immunological...
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| 格式: | Journal article |
| 语言: | English |
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Annual Reviews
2015
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| _version_ | 1826273392061317120 |
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| author | Bowness, P |
| author_facet | Bowness, P |
| author_sort | Bowness, P |
| collection | OXFORD |
| description | Possession of the human leukocyte antigen (HLA) class I molecule B27 is strongly associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown. Two broad theories most likely explain the role of HLA-B27 in AS pathogenesis. The first is based on the natural immunological function of HLA-B27 of presenting antigenic peptides to cytotoxic T cells. Thus, HLA-B27-restricted immune responses to self-antigens, or arthritogenic peptides, might drive immunopathology. B27 can also "behave badly," misfolding during assembly and leading to endoplasmic reticulum stress and autophagy responses. β2m-free B27 heavy chain structures including homodimers (B272) can also be expressed at the cell surface following endosomal recycling of cell surface heterotrimers. Cell surface free heavy chains and B272 bind to innate immune receptors on T, NK, and myeloid cells with proinflammatory effects. This review describes the natural function of HLA-B27, its disease associations, and the current theories as to its pathogenic role. |
| first_indexed | 2024-03-06T22:27:29Z |
| format | Journal article |
| id | oxford-uuid:572356a2-a2fd-4efc-bbfa-e03f789f6e25 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:27:29Z |
| publishDate | 2015 |
| publisher | Annual Reviews |
| record_format | dspace |
| spelling | oxford-uuid:572356a2-a2fd-4efc-bbfa-e03f789f6e252022-03-26T16:54:51ZHLA-B27Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:572356a2-a2fd-4efc-bbfa-e03f789f6e25EnglishSymplectic Elements at OxfordAnnual Reviews2015Bowness, PPossession of the human leukocyte antigen (HLA) class I molecule B27 is strongly associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown. Two broad theories most likely explain the role of HLA-B27 in AS pathogenesis. The first is based on the natural immunological function of HLA-B27 of presenting antigenic peptides to cytotoxic T cells. Thus, HLA-B27-restricted immune responses to self-antigens, or arthritogenic peptides, might drive immunopathology. B27 can also "behave badly," misfolding during assembly and leading to endoplasmic reticulum stress and autophagy responses. β2m-free B27 heavy chain structures including homodimers (B272) can also be expressed at the cell surface following endosomal recycling of cell surface heterotrimers. Cell surface free heavy chains and B272 bind to innate immune receptors on T, NK, and myeloid cells with proinflammatory effects. This review describes the natural function of HLA-B27, its disease associations, and the current theories as to its pathogenic role. |
| spellingShingle | Bowness, P HLA-B27 |
| title | HLA-B27 |
| title_full | HLA-B27 |
| title_fullStr | HLA-B27 |
| title_full_unstemmed | HLA-B27 |
| title_short | HLA-B27 |
| title_sort | hla b27 |
| work_keys_str_mv | AT bownessp hlab27 |