Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

Somatic cells acquire mutations throughout the course of an individual's life. Mutations occurring early in embryogenesis are often present in a substantial proportion of, but not all, cells in postnatal humans and thus have particular characteristics and effects. Depending on their location in...

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Bibliographic Details
Main Authors: Ju, Y, Martincorena, I, Gerstung, M, Petljak, M, Alexandrov, L, Rahbari, R, Wedge, D, Davies, H, Ramakrishna, M, Fullam, A, Martin, S, Alder, C, Patel, N, Gamble, S, O'Meara, S, Giri, D, Sauer, T, Pinder, S, Purdie, C, Borg, Å, Stunnenberg, H, van de Vijver, M, Tan, B, Caldas, C, Tutt, A, Ueno, N, van 't Veer, L, Martens, J, Sotiriou, C, Knappskog, S, Span, P, Lakhani, S, Eyfjörd, J, Børresen-Dale, A, Richardson, A, Thompson, A, Viari, A, Hurles, M, Nik-Zainal, S, Campbell, P, Stratton, M
Format: Journal article
Language:English
Published: Nature Publishing Group 2017

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