Diversity within the pRb pathway: is there a code of conduct?

Diversity within the pRb pathway: is there a code of conduct?

The failure of cell proliferation to be properly regulated is a hallmark of tumourigenesis. The retinoblastoma protein (pRb) pathway represents a key component in the regulation of the cell cycle and tumour suppression. Recent findings have revealed new levels of complexity reflecting a repertoire o...

ver descrição completa

Detalhes bibliográficos
Main Authors:	Munro, S, Carr, S, La Thangue, N
Formato:	Journal article
Idioma:	English
Publicado em:	2012

Registos relacionados

Lysine methylation regulates the pRb tumour suppressor protein.
Por: Munro, S, et al.
Publicado em: (2010)

Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.
Por: Carr, S, et al.
Publicado em: (2014)

Aberrant Expression of Rb and pRb-780, pRb-795 in Lung Adenocarcinoma Patients with EGFR Mutations and Their Clinical Significance
Por: Yunlong DONG, et al.
Publicado em: (2017-05-01)

Inhibition of pRB Pathway Differentially Modulates Apoptosis in Esophageal Cancer Cells
Por: Rossana C. Soletti, et al.
Publicado em: (2017-10-01)

Molecular analysis of the role of E2F proteins in the pRB pathway
Por: Moberg, Kenneth H. (Kenneth Harold), 1967-
Publicado em: (2009)

pRb's role in cell fate, lineage commitment, and tumorigenesis
Por: Calo-Velázquez, Eliezer
Publicado em: (2011)

CELLULAR RESPONSES TO DNA DAMAGE AND ONCOGENESIS BY THE p53 AND pRb/E2F PATHWAYS
Por: Elza Ibrahim Auerkari, et al.
Publicado em: (2015-07-01)

p130 And pRb in the Maintenance of Transient Quiescence of Mesenchymal Stem Cells
Por: Boris Popov, et al.
Publicado em: (2020-01-01)

Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation
Por: Danielian, Paul S., et al.
Publicado em: (2015)

Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb
Por: Mittnacht Sibylle, et al.
Publicado em: (2006-02-01)

CENPA overexpression promotes genome instability in pRb-depleted human cells
Por: Lentini Laura, et al.
Publicado em: (2009-12-01)

CDK4, pRB and E2F1: connected to insulin
Por: Blanchet Emilie, et al.
Publicado em: (2010-02-01)

Loss of heterozygosity for Rb locus and pRb immunostaining in laryngeal cancer: a clinicopathologic, molecular and immunohistochemical study.
Por: Andrzej Borzecki, et al.
Publicado em: (2009-01-01)

An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence
Por: Ashworth Alan, et al.
Publicado em: (2011-07-01)

E2F4 cooperates with pRB in the development of extra-embryonic tissues
Por: Lee, Eunice Y., et al.
Publicado em: (2012)

Immunoexpression of pRb and EGFR using tissue microarray (TMA) technique - a preliminary study
Por: Kipli, N.P., et al.
Publicado em: (2006)

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation
Por: Nicolay, Brandon N., et al.
Publicado em: (2016)

Simultaneous Analysis of the p16 Gene and Protein in Canine Lymphoma Cells and Their Correlation with pRb Phosphorylation
Por: Leni Maylina, et al.
Publicado em: (2022-07-01)

Nrf2 affects hydroquinone-induces cell cycle arrest through the p16/pRb signaling pathway and antioxidant enzymes
Por: Lin Chen, et al.
Publicado em: (2023-01-01)

The in vivo role of the RP-Mdm2-p53 pathway in signaling oncogenic stress induced by pRb inactivation and Ras overexpression.
Por: Wenqi Pan, et al.
Publicado em: (2011-01-01)

MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation
Por: Jian Ma, et al.
Publicado em: (2024-02-01)

pRb-Independent Growth Arrest and Transcriptional Regulation of E2F Target Genes
Por: Michael T. McCabe, et al.
Publicado em: (2005-02-01)

Expression of p53, pRb, Ki-67 and bcl-2 in betel quid induced oral mucosal lesions
Por: Kipli, N.P., et al.
Publicado em: (2005)

Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development.
Por: Megan E Spurgeon, et al.
Publicado em: (2022-05-01)

Culturing on Wharton's jelly extract delays mesenchymal stem cell senescence through p53 and p16INK4a/pRb pathways.
Por: Haojie Hao, et al.
Publicado em: (2013-01-01)

Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb.
Por: Mi, D, et al.
Publicado em: (2013)

The correlation between HPV infection and p53, pRb, KI-67 as well as tunnel expression of cervical carcinoma
Por: Perpustakaan UGM, i-lib
Publicado em: (2007)

Inactivation of CDK/pRb pathway normalizes survival pattern of lymphoblasts expressing the FTLD-progranulin mutation c.709-1G>A.
Por: Carolina Alquezar, et al.
Publicado em: (2012-01-01)

Lysine methylation and the regulation of p53.
Por: Carr, S, et al.
Publicado em: (2012)

Mutation of the LXCXE binding cleft of pRb facilitates transformation by ras in vitro but does not promote tumorigenesis in vivo.
Por: Srikanth Talluri, et al.
Publicado em: (2013-01-01)

Functional ablation of pRb activates Cdk2 and causes antiestrogen resistance in human breast cancer cells.
Por: Hemant Varma, et al.
Publicado em: (2007-12-01)

Expression of Cell-Cycle Regulatory Proteins pRb, Cyclin D1, and p53 Is Not Associated with Recurrence Rates of Equine Sarcoids
Por: Giorgia Tura, et al.
Publicado em: (2022-09-01)

Effects of high-risk human papillomavirus infection on P53, pRb, and survivin in lung adenocarcinoma—a retrospective study
Por: Wenwen Sun, et al.
Publicado em: (2023-07-01)

Potent anti-tumor effect generated by a novel human papillomavirus (HPV) antagonist peptide reactivating the pRb/E2F pathway.
Por: Cai-ping Guo, et al.
Publicado em: (2011-01-01)

Spatio-Temporal Expression Pattern of Ki-67, pRB, MMP-9 and Bax in Human Secondary Palate Development
Por: Tanja Šimić Bilandžija, et al.
Publicado em: (2021-02-01)

E2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity
Por: Fikret Sahin, Todd L. Sladek
Publicado em: (2010-01-01)

Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex
Por: Jeroen J.M Hoozemans, et al.
Publicado em: (2004-04-01)

Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma
Por: Michaela Plath, et al.
Publicado em: (2018-09-01)

Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors
Por: Jin Hwan Kim, et al.
Publicado em: (2014-03-01)

PRB report /
Por: Population Reference Bureau
Publicado em: (1974)