Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin
Breaks in DNA strands recruit the protein PARP1 and its paralogue PARP2 to modify histones and other substrates through the addition of mono- and poly(ADP-ribose) (PAR)1,2,3,4,5. In the DNA damage responses, this post-translational modification occurs predominantly on serine residues6,7,8 and requir...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2020
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