Estimating diversifying selection and functional constraint in the presence of recombination.

Models of molecular evolution that incorporate the ratio of nonsynonymous to synonymous polymorphism (dN/dS ratio) as a parameter can be used to identify sites that are under diversifying selection or functional constraint in a sample of gene sequences. However, when there has been recombination in...

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Bibliographic Details
Main Authors: Wilson, D, McVean, G
Format: Journal article
Language:English
Published: 2006