Estimating diversifying selection and functional constraint in the presence of recombination.
Models of molecular evolution that incorporate the ratio of nonsynonymous to synonymous polymorphism (dN/dS ratio) as a parameter can be used to identify sites that are under diversifying selection or functional constraint in a sample of gene sequences. However, when there has been recombination in...
Main Authors: | Wilson, D, McVean, G |
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Format: | Journal article |
Language: | English |
Published: |
2006
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