Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA)

The biological properties of TNF-alpha make it a candidate therapeutic target in RA. Our studies have demonstrated that TNF-alpha and its receptors are up-regulated and co-expressed in the synovium and cartilage-pannus junction of RA joints. Neutralizing TNF-alpha antibodies reduce the production of...

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Detalhes bibliográficos
Main Authors: Maini, R, Elliott, M, Brennan, F, Feldmann, M
Formato: Journal article
Idioma:English
Publicado em: 1995