Structure of the helicase domain of DNA polymerase theta reveals a possible role in the microhomology-mediated end-joining pathway
DNA polymerase theta (Polθ) has been identified as a crucial alternative non-homologous end-joining factor in mammalian cells. Polθ is upregulated in a range of cancer cell types defective in homologous recombination, and knockdown has been shown to inhibit cell survival in a subset of these, making...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2015
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