Multiomics and spatial mapping characterizes human CD8+ T cell states in cancer

Multiomics and spatial mapping characterizes human CD8+ T cell states in cancer

Clinically relevant immunological biomarkers that discriminate between diverse hypofunctional states of tumor-associated CD8+ T cells remain disputed. Using multiomics analysis of CD8+ T cell features across multiple patient cohorts and tumor types, we identified tumor niche–dependent exhausted and...

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Détails bibliographiques
Auteurs principaux: Naulaerts, S, Datsi, A, Borras, DM, Antoranz Martinez, A, Messiaen, J, Vanmeerbeek, I, Sprooten, J, Laureano, RS, Govaerts, J, Panovska, D, Derweduwe, M, Sabel, MC, Rapp, M, Ni, W, Mackay, S, Van Herck, Y, Gelens, L, Venken, T, More, S, Bechter, O, Bergers, G, Liston, A, De Vleeschouwer, S, Van Den Eynde, BJ, Lambrechts, D, Verfaillie, M, Bosisio, F, Tejpar, S, Borst, J, Sorg, RV, De Smet, F, Garg, AD
Format: Journal article
Langue:English
Publié: American Association for the Advancement of Science 2023

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