Multiomics and spatial mapping characterizes human CD8+ T cell states in cancer

Multiomics and spatial mapping characterizes human CD8+ T cell states in cancer

Clinically relevant immunological biomarkers that discriminate between diverse hypofunctional states of tumor-associated CD8+ T cells remain disputed. Using multiomics analysis of CD8+ T cell features across multiple patient cohorts and tumor types, we identified tumor niche–dependent exhausted and...

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Hlavní autoři: Naulaerts, S, Datsi, A, Borras, DM, Antoranz Martinez, A, Messiaen, J, Vanmeerbeek, I, Sprooten, J, Laureano, RS, Govaerts, J, Panovska, D, Derweduwe, M, Sabel, MC, Rapp, M, Ni, W, Mackay, S, Van Herck, Y, Gelens, L, Venken, T, More, S, Bechter, O, Bergers, G, Liston, A, De Vleeschouwer, S, Van Den Eynde, BJ, Lambrechts, D, Verfaillie, M, Bosisio, F, Tejpar, S, Borst, J, Sorg, RV, De Smet, F, Garg, AD
Médium: Journal article
Jazyk:English
Vydáno: American Association for the Advancement of Science 2023

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