An efficient asymmetric synthesis of (-)-lupinine.

The asymmetric synthesis of (-)-lupinine was achieved in 8 steps, 15% overall yield and >99 : 1 dr from commercially available starting materials. The strategy used for the construction of the quinolizidine scaffold involved reaction of an enantiopure tertiary dibenzylamine via two sequential...

Полное описание

Библиографические подробности
Главные авторы: Davies, S, Fletcher, A, Foster, E, Houlsby, I, Roberts, P, Schofield, T, Thomson, J
Формат: Journal article
Язык:English
Опубликовано: Royal Society of Chemistry 2014
Описание
Итог:The asymmetric synthesis of (-)-lupinine was achieved in 8 steps, 15% overall yield and >99 : 1 dr from commercially available starting materials. The strategy used for the construction of the quinolizidine scaffold involved reaction of an enantiopure tertiary dibenzylamine via two sequential ring-closures which both occurred with concomitant N-debenzylation.