First-in-class inhibitors of the ribosomal oxygenase MINA53

MINA53 is a JmjC domain 2-oxoglutarate dependent oxygenase that catalyzes ribosomal hydroxylation and which is a target of the oncogenic transcription factor c-MYC. Despite its anticancer target potential, no small molecule MINA53 inhibitors are reported. Using ribosomal substrate fragments, we deve...

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Bibliographic Details
Main Authors:	Nowak, R, Tumber, A, Hendrix, E, Ansari, M, Sabatino, M, Antonini, L, Andrijes, R, Salah, E, Mautone, N, Pellegrini, F, Simelis, K, Kawamura, A, Johansson, C, Passeri, D, Pellicciari, R, Ciogli, A, Del Bufalo, D, Ragno, R, Coleman, M, Trisciuoglio, D, Mai, A, Oppermann, U, Schofield, C, Rotili, D
Format:	Journal article
Language:	English
Published:	American Chemical Society 2021

First-in-class inhibitors of the ribosomal oxygenase MINA53

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