2-amino-2, 3-dihydro-1H-indene-5-carboxamide-based discoidin domain receptors 1 (DDR1) inhibitors: design, synthesis, and in vivo anti-pancreatic cancer efficacy

A series of 2-amino-2,3-dihydro-1H-indene-5-carboxamides were designed and synthesized as new selective discoidin domain receptor 1 (DDR1) inhibitors. One of the representative compounds, 7f, bound with DDR1 with a Kd value of 5.9 nM and suppressed the kinase activity with an half-maximal (50%) inhi...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Zhu, D, Huang, H, Pinkas, D, Luo, J, Ganguly, D, Fox, A, Arner, E, Xiang, Q, Tu, Z, Bullock, A, Brekken, R, Ding, K, Lu, X
Fformat: Journal article
Iaith:English
Cyhoeddwyd: American Chemical Society 2019