Design of a biased potent small molecule inhibitor of the bromodomain and PHD finger-containing (BRPF) proteins suitable for cellular and in vivo studies.

The BRPF (bromodomain and PHD finger-containing) family are scaffolding proteins important for the recruitment of histone acetyltransferases of the MYST family to chromatin. Evaluation of the BRPF family as a potential drug target is at an early stage although th...

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Bibliographic Details
Main Authors:	Igoe, N, Bayle, E, Fedorov, O, Tallant, C, Savitsky, P, Rogers, C, Owen, D, Deb, G, Somervaille, T, Andrews, D, Jones, N, Cheasty, A, Ryder, H, Brennan, P, Müller, S, Knapp, S, Fish, P
Format:	Journal article
Language:	English
Published:	American Chemical Society 2017

Design of a biased potent small molecule inhibitor of the bromodomain and PHD finger-containing (BRPF) proteins suitable for cellular and in vivo studies.

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