Landscape of X chromosome inactivation across human tissues

X chromosome inactivation (XCI) silences transcription from one of the two X chromosomes in female mammalian cells to balance expression dosage between XX females and XY males. XCI is, however, incomplete in humans: up to one-third of X-chromosomal genes are expressed from both the active and inacti...

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Bibliographic Details
Main Authors: Tukiainen, T, Villani, A-C, Yen, A, Rivas, MA, Marshall, JL, Satija, R, Aguirre, M, Gauthier, L, Fleharty, M, Kirby, A, Cummings, BB, Castel, SE, Karczewski, KJ, Aguet, F, Byrnes, A, GTEx Consortium, Lappalainen, T, Regev, A, Ardlie, KG, Hacohen, N, MacArthur, DG
Format: Journal article
Language:English
Published: Springer Nature 2017