Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia

Avian influenza A (H5N1) viruses cause severe disease in humans, but the basis for their virulence remains unclear. In vitro and animal studies indicate that high and disseminated viral replication is important for disease pathogenesis. Laboratory experiments suggest that virus-induced cytokine dysr...

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Main Authors: De Jong, M, Simmons, C, Thanh, T, Hien, V, Smith, G, Chau, T, Hoang, D, Chau, N, Khanh, T, Dong, V, Qui, P, Cam, B, Ha, D, Guan, Y, Peiris, J, Chinh, N, Hien, T, Farrar, J
格式: Journal article
语言:English
出版: Nature 2006