NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma

Pain is a central feature of soft tissue trauma, which under certain contexts, results in aberrant osteochondral differentiation of tissue-specific stem cells. Here, the role of sensory nerve fibers in this abnormal cell fate decision is investigated using a severe extremity injury model in mice. So...

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Bibliographic Details
Main Authors: Lee, S, Hwang, C, Marini, S, Tower, RJ, Qin, Q, Negri, S, Pagani, CA, Sun, Y, Stepien, DM, Sorkin, M, Kubiak, CA, Visser, ND, Meyers, CA, Wang, Y, Rasheed, HA, Xu, J, Miller, S, Huber, AK, Minichiello, L, Cederna, PS, Kemp, SWP, Clemens, TL, James, AW, Levi, B
Format: Journal article
Language:English
Published: Springer Nature 2021