Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.

UNLABELLED: Inhibition of malonyl-coenzyme A decarboxylase (MCD) shifts metabolism from fatty acid towards glucose oxidation, which has therapeutic potential for obesity and myocardial ischemic injury. However, ~40% of patients with MCD deficiency are diagnosed with cardiomyopathy during infancy. AI...

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Những tác giả chính: Aksentijević, D, McAndrew, D, Karlstädt, A, Zervou, S, Sebag-Montefiore, L, Cross, R, Douglas, G, Regitz-Zagrosek, V, Lopaschuk, G, Neubauer, S, Lygate, C
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Academic Press 2014