Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target

Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target

The requirement for next-generation antimalarials to be both curative and transmission-blocking necessitates the identification of previously undiscovered druggable molecular pathways. We identified a selective inhibitor of the Plasmodium falciparum protein kinase PfCLK3, which we used in combinatio...

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Bibliographic Details
Main Authors: Alam, MM, Sanchez-Azqueta, A, Janha, O, Flannery, EL, Mahindra, A, Mapesa, K, Char, AB, Sriranganadane, D, Brancucci, NMB, Antonova-Koch, Y, Crouch, K, Simwela, NV, Millar, SB, Akinwale, J, Mitcheson, D, Solyakov, L, Dudek, K, Jones, C, Zapatero, C, Doerig, C, Nwakanma, DC, Vázquez, MJ, Colmenarejo, G, Lafuente-Monasterio, MJ, Leon, ML, Godoi, PHC, Elkins, JM, Waters, AP, Jamieson, AG, Álvaro, EF, Ranford-Cartwright, LC, Marti, M, Winzeler, EA, Gamo, FJ, Tobin, AB
Format: Journal article
Language:English
Published: American Association for the Advancement of Science 2019

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