Activated invariant NKT cells regulate osteoclast development and function.
Invariant NKT (iNKT) cells modulate innate and adaptive immune responses through activation of myeloid dendritic cells and macrophages and via enhanced clonogenicity, differentiation, and egress of their shared myeloid progenitors. Because these same progenitors give rise to osteoclasts (OCs), which...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Association of Immunologists
2011
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| _version_ | 1797070106528841728 |
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| author | Hu, M Bassett, J Danks, L Howell, P Xu, K Spanoudakis, E Kotsianidis, I Boyde, A Williams, G Horwood, N Roberts, I Karadimitris, A |
| author_facet | Hu, M Bassett, J Danks, L Howell, P Xu, K Spanoudakis, E Kotsianidis, I Boyde, A Williams, G Horwood, N Roberts, I Karadimitris, A |
| author_sort | Hu, M |
| collection | OXFORD |
| description | Invariant NKT (iNKT) cells modulate innate and adaptive immune responses through activation of myeloid dendritic cells and macrophages and via enhanced clonogenicity, differentiation, and egress of their shared myeloid progenitors. Because these same progenitors give rise to osteoclasts (OCs), which also mediate the egress of hematopoietic progenitors and orchestrate bone remodeling, we hypothesized that iNKT cells would extend their myeloid cell regulatory role to the development and function of OCs. In this study, we report that selective activation of iNKT cells by α-galactosylceramide causes myeloid cell egress, enhances OC progenitor and precursor development, modifies the intramedullary kinetics of mature OCs, and enhances their resorptive activity. OC progenitor activity is positively regulated by TNF-α and negatively regulated by IFN-γ, but is IL-4 and IL-17 independent. These data demonstrate a novel role of iNKT cells that couples osteoclastogenesis with myeloid cell egress in conditions of immune activation. |
| first_indexed | 2024-03-06T22:34:19Z |
| format | Journal article |
| id | oxford-uuid:595bcb43-8dfc-46c7-a922-6824a4705398 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:34:19Z |
| publishDate | 2011 |
| publisher | American Association of Immunologists |
| record_format | dspace |
| spelling | oxford-uuid:595bcb43-8dfc-46c7-a922-6824a47053982022-03-26T17:09:15ZActivated invariant NKT cells regulate osteoclast development and function.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:595bcb43-8dfc-46c7-a922-6824a4705398EnglishSymplectic Elements at OxfordAmerican Association of Immunologists2011Hu, MBassett, JDanks, LHowell, PXu, KSpanoudakis, EKotsianidis, IBoyde, AWilliams, GHorwood, NRoberts, IKaradimitris, AInvariant NKT (iNKT) cells modulate innate and adaptive immune responses through activation of myeloid dendritic cells and macrophages and via enhanced clonogenicity, differentiation, and egress of their shared myeloid progenitors. Because these same progenitors give rise to osteoclasts (OCs), which also mediate the egress of hematopoietic progenitors and orchestrate bone remodeling, we hypothesized that iNKT cells would extend their myeloid cell regulatory role to the development and function of OCs. In this study, we report that selective activation of iNKT cells by α-galactosylceramide causes myeloid cell egress, enhances OC progenitor and precursor development, modifies the intramedullary kinetics of mature OCs, and enhances their resorptive activity. OC progenitor activity is positively regulated by TNF-α and negatively regulated by IFN-γ, but is IL-4 and IL-17 independent. These data demonstrate a novel role of iNKT cells that couples osteoclastogenesis with myeloid cell egress in conditions of immune activation. |
| spellingShingle | Hu, M Bassett, J Danks, L Howell, P Xu, K Spanoudakis, E Kotsianidis, I Boyde, A Williams, G Horwood, N Roberts, I Karadimitris, A Activated invariant NKT cells regulate osteoclast development and function. |
| title | Activated invariant NKT cells regulate osteoclast development and function. |
| title_full | Activated invariant NKT cells regulate osteoclast development and function. |
| title_fullStr | Activated invariant NKT cells regulate osteoclast development and function. |
| title_full_unstemmed | Activated invariant NKT cells regulate osteoclast development and function. |
| title_short | Activated invariant NKT cells regulate osteoclast development and function. |
| title_sort | activated invariant nkt cells regulate osteoclast development and function |
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