Parkinson disease, LRRK2 and the endocytic-autophagic pathway.

Parkinson disease, LRRK2 and the endocytic-autophagic pathway.

Neurons are quiescent cells that survive for several decades, many times the turnover time of most organelles and proteins, and so with advancing age neurons become affected by degenerative diseases. Autophagy is thought to be an important cellular mechanism preventing cell degeneration in such long...

书目详细资料
Main Authors:	Alegre-Abarrategui, J, Wade-Martins, R
格式:	Journal article
语言:	English
出版:	2009

相似书籍

LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease.
由: Alegre-Abarrategui, J, et al.
出版: (2008)

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model.
由: Alegre-Abarrategui, J, et al.
出版: (2009)

Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models.
由: Sloan, M, et al.
出版: (2012)

An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2
由: Connor-Robson, N, et al.
出版: (2019)

Convergent pathways in Parkinson’s disease
由: Cherubini, M, et al.
出版: (2017)

Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2
由: Singh, Ranjan K, et al.
出版: (2023)

Dysregulation of dopamine metabolism in LRRK2-associated Parkinson's disease.
由: Chan, Clarice Zi Ying.
出版: (2013)

The study of dopamine metabolism with LRRK2 variants in Parkinson’s disease
由: Kwok, Wei Hao
出版: (2015)

Investigating the effects of autophagic perturbations on mitochondrial function in Parkinson’s Disease
由: Ryan Barlow Patterson
出版: (2019)

Understanding the role of LRRK2 in protein translation - implications for Parkinson's disease.
由: Cheng, Yue Xiang.
出版: (2010)

A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2, SNCA and MAPT BAC-transgenic mice.
由: Johnson, S, et al.
出版: (2011)

LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease
由: Lee, H, et al.
出版: (2017)

Molecular characterisation of autophagy deficits in a LRRK2-BAC transgenic rat model of Parkinson’s disease
由: Wallings, R
出版: (2018)

RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis/frontotemporal dementia disease continuum.
由: Thomas, M, et al.
出版: (2013)

UNDERSTANDING THE EARLY PATHOLOGICAL PATHWAYS IN PARKINSON'S DISEASE. THE OXFORD PARKINSON'S DISEASE CENTRE
由: Hu, M, et al.
出版: (2010)

Investigation of the endocytic pathway of ADAMTS-4
由: Owen, K, et al.
出版: (2009)

RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes
由: Booth, H, et al.
出版: (2019)

The behavioural and molecular characterisation of a novel LRRK2 BAC transgenic rat model of Parkinson’s disease
由: Sloan, M, et al.
出版: (2014)

LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
由: Sloan, M, et al.
出版: (2016)

Glucosylceramide modulates membrane traffic along the endocytic pathway.
由: Sillence, D, et al.
出版: (2002)

Effect of stress on neuroinflammation in the substantia nigra and striatum of LRRK2 (R1441G) mouse model for Parkinson’s disease
由: Chen, Jiayi
出版: (2015)

LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function
由: Wallings, R, et al.
出版: (2019)

Targeting TFEB and TFE3 in iPSC-derived dopaminergic neurons to correct autophagic/lysosomal deficits in Parkinson's disease
由: McGuinness, W
出版: (2023)

ER stress and autophagic perturbations lead to elevated extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-derived dopamine neurons
由: Fernandes, H, et al.
出版: (2016)

Are rodent models of Parkinson's disease behaving as they should?
由: Vingill, S, et al.
出版: (2017)

The role of astrocyte dysfunction in Parkinson's disease pathogenesis
由: Booth, H, et al.
出版: (2017)

α-Synuclein and dopamine at the crossroads of Parkinson's disease.
由: Venda, L, et al.
出版: (2010)

Endocytic pathways of TIMP-3 and its N-terminal inhibitory domain
由: Scilabra, S, et al.
出版: (2009)

Invariant chain regulation of MHC class II function in the secretory and endocytic pathways
由: Germain, R, et al.
出版: (1997)

Dysregulated dopamine metabolism in LRRK2 mutants
由: Chia, Xin Tian
出版: (2015)

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease.
由: Boland, B, et al.
出版: (2008)

A Novel Genomic DNA-Reporter Gene Model for the Study of Friedreich's Ataxia in Neuronal Cells
由: Lufino, M, et al.
出版: (2009)

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells
由: Smith, A, et al.
出版: (2018)

Perturbed molecular pathways in Parkinson's disease
由: Millin, S
出版: (2017)

Targeting alpha-synuclein as a therapy for Parkinson’s disease
由: Fields, CR, et al.
出版: (2019)

Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
由: Ryan, B, et al.
出版: (2014)

Alpha-synuclein oligomers: a new hope.
由: Bengoa-Vergniory, N, et al.
出版: (2017)

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.
由: Ryan, B, et al.
出版: (2015)

What is our understanding of the influence of gut microbiota on the pathophysiology of Parkinson’s disease?
由: Hill, A, et al.
出版: (2021)

Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease.
由: Beevers, J, et al.
出版: (2013)