Total synthesis of the Fusarium toxin equisetin.

A short stereoselective synthesis of the Fusarium toxin equisetin, a potent inhibitor of HIV-1 integrase enzyme is described, using as the key step a stereoselective intramolecular Diels-Alder reaction of a fully conjugated E,E,E-triene with a trisubstituted gamma,delta-unsaturated beta-ketothioeste...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Burke, LT, Dixon, D, Ley, S, Rodríguez, F
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2005