Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Mutant calreticulin (CALR) proteins resulting from a −1/+2 frameshifting mutation of the CALR exon 9 carry a novel C-terminal amino acid sequence and drive the development of myeloproliferative neoplasms (MPNs). Mutant CALRs were shown to interact with and activate the thrombopoietin receptor (TpoR/...

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Main Authors: Pecquet, C, Papadopoulos, N, Balligand, T, Chachoua, I, Tisserand, A, Vertenoeil, G, Nédélec, A, Vertommen, D, Roy, A, Marty, C, Nivarthi, H, Defour, J-P, El-Khoury, M, Hug, E, Majoros, A, Xu, E, Zagrijtschuk, O, Fertig, TE, Marta, DS, Gisslinger, H, Gisslinger, B, Schalling, M, Casetti, I, Rumi, E, Pietra, D, Cavalloni, C, Arcaini, L, Cazzola, M, Komatsu, N, Kihara, Y, Sunami, Y, Edahiro, Y, Araki, M, Lesyk, R, Buxhofer-Ausch, V, Heibl, S, Pasquier, F, Havelange, V, Plo, I, Vainchenker, W, Kralovics, R, Constantinescu, SN
Format: Journal article
Language:English
Published: American Society of Hematology 2022

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