Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.

gamma-Aminobutyric acid (GABA) has been proposed to function as a paracrine signaling molecule in islets of Langerhans. We have shown that rat beta-cells release GABA by Ca(2+)-dependent exocytosis of synaptic-like microvesicles. Here we demonstrate that GABA thus released can diffuse over sufficien...

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Bibliografski detalji
Glavni autori: Wendt, A, Birnir, B, Buschard, K, Gromada, J, Salehi, A, Sewing, S, Rorsman, P, Braun, M
Format: Journal article
Jezik:English
Izdano: 2004