Recombination-mediated escape from primary CD8+T cells in acute HIV-1 infection

Recombination-mediated escape from primary CD8+T cells in acute HIV-1 infection

Background: A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape.Results: Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who w...

书目详细资料
Main Authors:	Ritchie, A, Cai, F, Smith, N, Chen, S, Song, H, Brackenridge, S, Karim, S, Korber, B, Mcmichael, A, Gao, F, Goonetilleke, N
格式:	Journal article
语言:	English
出版:	BioMed Central 2014

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