Age-dependent decline in cardiac function in guanidinoacetate-N-methyltransferase knockout mice
Aim:Guanidinoacetate N-methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well tolerated as GAMT-/- mice exhibit normal exercise capacity and response to ischemic heart failure. However, we hypothesized long-term consequen...
Asıl Yazarlar: | , , , , , , , |
---|---|
Materyal Türü: | Journal article |
Dil: | English |
Baskı/Yayın Bilgisi: |
Frontiers Media
2019
|