Age-dependent decline in cardiac function in guanidinoacetate-N-methyltransferase knockout mice

Age-dependent decline in cardiac function in guanidinoacetate-N-methyltransferase knockout mice

Aim:Guanidinoacetate N-methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well tolerated as GAMT-/- mice exhibit normal exercise capacity and response to ischemic heart failure. However, we hypothesized long-term consequen...

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Bibliografiska uppgifter
Huvudupphovsmän:	Aksentijević, D, Zervou, S, Eykyn, TR, McAndrew, DJ, Lygate, CA, Wallis, J, Schneider, JE, Neubauer, S
Materialtyp:	Journal article
Språk:	English
Publicerad:	Frontiers Media 2019

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