A novel inhibitor of complement C5 provides structural insights into activation

Abstract The complement system is a crucial part of innate immune defences against invading pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must therefore rely on inhibitors to counter complement activation. We have identified a novel class of inhibitors f...

Full description

Bibliographic Details
Main Authors: Reichhardt, M, Johnson, S, Tang, T, Morgan, T, Tebeka, N, Popitsch, N, Deme, J, Jore, M, Lea, S
Format: Working paper
Published: 2019