BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution

The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1, and RMI2 to form the BTR complex, which dissolves double Holliday junctions and DNA replication intermediates to promote sister chromatid disjunction before cell division. In its absence, structure-specific nucleases li...

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Bibliografske podrobnosti
Main Authors: Tsukada, K, Jones, SE, Bannister, J, Durin, M-A, Vendrell, I, Fawkes, M, Fischer, R, Kessler, BM, Chapman, JR, Blackford, AN
Format: Journal article
Jezik:English
Izdano: Cell Press 2024