BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution

BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution

The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1, and RMI2 to form the BTR complex, which dissolves double Holliday junctions and DNA replication intermediates to promote sister chromatid disjunction before cell division. In its absence, structure-specific nucleases li...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Tsukada, K, Jones, SE, Bannister, J, Durin, M-A, Vendrell, I, Fawkes, M, Fischer, R, Kessler, BM, Chapman, JR, Blackford, AN
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	Cell Press 2024

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