Synthesis and biological evaluation of phospholane and dihydrophosphole analogues of the glutamate receptor agonist AP4

Synthesis and biological evaluation of phospholane and dihydrophosphole analogues of the glutamate receptor agonist AP4

The syntheses and preliminary pharmacological characterisation of two novel cyclic phosphinic acid-containing amino acids designed as conformationally restricted analogues of the metabotropic glutamate receptor agonist AP4 (1) are reported.

Bibliografische gegevens
Hoofdauteurs:	Conway, S, Miller, J, Bond, A, Clark, B, Jane, D
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2002

Gelijkaardige items

Aluminacyclopentanes in the synthesis of 3-substituted phospholanes and α,ω-bisphospholanes
door: Vladimir A. D’yakonov, et al.
Gepubliceerd in: (2016-03-01)

Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors.
door: Conway, S, et al.
Gepubliceerd in: (2001)

Metabotropic glutamate receptor agonists for schizophrenia.
door: Harrison, P
Gepubliceerd in: (2008)

Synthesis of analogues of lycoperdic acid to probe glutamate receptors in the central nervous system
door: Goundry, W, et al.
Gepubliceerd in: (2003)

Synephrine Analogues as Glucocorticoid Receptor Agonists
door: Eugenia Oleynik, et al.
Gepubliceerd in: (2023-11-01)

Structural requirements for selective group III metabotropic glutamate receptor antagonists based on the phenylglycine nucleus.
door: Jane, D, et al.
Gepubliceerd in: (2002)

Novel phenylglycine analogues as potent and selective antagonists of group III mGlu receptors on neonatal rat primary afferent terminals.
door: Miller, J, et al.
Gepubliceerd in: (2000)

Computational study of synthetic agonist ligands of ionotropic glutamate receptors.
door: Tino Wolter, et al.
Gepubliceerd in: (2013-01-01)

Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals.
door: Miller, J, et al.
Gepubliceerd in: (2003)

The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor.
door: Bryan L Roth, et al.
Gepubliceerd in: (2013-01-01)

Correction: Computational Study of Synthetic Agonist Ligands of Ionotropic Glutamate Receptors
Gepubliceerd in: (2014-01-01)

Correction: Computational Study of Synthetic Agonist Ligands of Ionotropic Glutamate Receptors.
door: Tino Wolter, et al.
Gepubliceerd in: (2014-01-01)

Correction: The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor.
door: Bryan L Roth, et al.
Gepubliceerd in: (2018-01-01)

A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity
door: Stanley, N.J., et al.
Gepubliceerd in: (2010)

Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation
door: Veerapen, N, et al.
Gepubliceerd in: (2011)

Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation.
door: Veerapen, N, et al.
Gepubliceerd in: (2011)

Synthesis and Biological Evaluation of Novel Biased Mu-Opioid Receptor Agonists
door: Yanhao Guo, et al.
Gepubliceerd in: (2024-06-01)

Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists
door: Wenjing Sun, et al.
Gepubliceerd in: (2023-06-01)

Binding site flexibility: Molecular simulation of partial and full agonists within a glutamate receptor
door: Arinaminpathy, Y, et al.
Gepubliceerd in: (2006)

Binding site flexibility: molecular simulation of partial and full agonists within a glutamate receptor.
door: Arinaminpathy, Y, et al.
Gepubliceerd in: (2006)

Effects of glutamate receptor agonists on the P13 auditory evoked potential and startle response in the rat
door: Christen eSimon, et al.
Gepubliceerd in: (2011-01-01)

Direct versatile route to conformationally constrained glutamate analogues
door: Dyer, J, et al.
Gepubliceerd in: (1998)

Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
door: Min-Juan Wang, et al.
Gepubliceerd in: (2013-01-01)

Synthesis and biological evaluation of novel eunicellin analogues
door: Gilmour, R, et al.
Gepubliceerd in: (2005)

Inositol polyphosphates and analogues: synthesis & chemical biology
door: Shipton, M
Gepubliceerd in: (2021)

The synthesis and biological evaluation of novel eunicellin analogues
door: Davidson, J, et al.
Gepubliceerd in: (2004)

Synthesis and Biological Evaluation of New CRH Analogues
door: Spyridon Papazacharias, et al.
Gepubliceerd in: (2010-01-01)

Synthesis and Biological Evaluation of Aminobisphosphonates—Analogues of Incadronate
door: Ewa Chmielewska, et al.
Gepubliceerd in: (2019-08-01)

Synthesis and Biological Evaluation of Carbocyclic Analogues of Pachastrissamine
door: Yongseok Kwon, et al.
Gepubliceerd in: (2015-02-01)

Molecular determinants of agonist selectivity in glutamate-gated chloride channels which likely explain the agonist selectivity of the vertebrate glycine and GABAA-ρ receptors.
door: Thomas Blarre, et al.
Gepubliceerd in: (2014-01-01)

Minimal Structural Changes Determine Full and Partial Nicotinic Receptor Agonist Activity for Nicotine Analogues
door: Juan Pablo Gonzalez-Gutierrez, et al.
Gepubliceerd in: (2019-07-01)

Defense reaction induced by a metabotropic glutamate receptor agonist microinjected into the dorsal periaqueductal gray of rats
door: M.L. Molchanov, et al.
Gepubliceerd in: (1999-12-01)

The sigma1 receptor agonist enhances long-term depression caused by activation of metabotropic glutamate receptors in rat hippocampal neurons
door: Pavel D. Rogozin, et al.
Gepubliceerd in: (2018-12-01)

Synthesis and Biological Properties of Novel Fluoroprostaglandin Derivatives: Highly Selective and Potent Agonists for Prostaglandin Receptors
door: Yasushi Matsumuraa, et al.
Gepubliceerd in: (2004-03-01)

Correction: Molecular Determinants of Agonist Selectivity in Glutamate-Gated Chloride Channels Which Likely Explain the Agonist Selectivity of the Vertebrate Glycine and GABAA-ρ Receptors
Gepubliceerd in: (2014-01-01)

Correction: Molecular Determinants of Agonist Selectivity in Glutamate-Gated Chloride Channels Which Likely Explain the Agonist Selectivity of the Vertebrate Glycine and GABA-ρ Receptors.
Gepubliceerd in: (2014-01-01)

<it>In vivo </it>antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera
door: Guillemyn Karel, et al.
Gepubliceerd in: (2012-01-01)

Synthesis of Polyfluorinated KRN7000 Analogues and Biological Implications
door: M. Isabel Matheu, et al.
Gepubliceerd in: (2019-08-01)

Synthesis, reactivity and biological activity of 5-alkoxymethyluracil analogues
door: Lucie Brulikova, et al.
Gepubliceerd in: (2011-05-01)

Glutamate receptor activation is involved in 5-HT2 agonist-induced Arc gene expression in the rat cortex.
door: Pei, Q, et al.
Gepubliceerd in: (2004)