Interpretation of somatic POLE mutations in endometrial carcinoma

Pathogenic somatic missense mutations within the DNA polymerase epsilon (POLE) exonuclease domain define the important subtype of ultramutated tumours (‘POLE‐ultramutated’) within the novel molecular classification of endometrial carcinoma (EC). However, clinical implementation of this classifier re...

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Bibliographic Details
Main Authors: León-Castillo, A, Britton, H, McConechy, MK, McAlpine, JN, Nout, R, Kommoss, S, Brucker, SY, Carlson, JW, Epstein, E, Rau, TT, Bosse, T, Church, DN, Gilks, CB
Format: Journal article
Language:English
Published: Wiley 2020