Directed synthesis of all four pure stereoisomers of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A

The first preparation of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A and its likewise naturally occurring minor atropisomer, in an atropisomerically pure form, is described. The synthesis succeeded by resolution of the already rotationally hindered, and thus atropo-diastereomer...

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Bibliographic Details
Main Authors: Seupel, R, Hertlein-Amslinger, B, Gulder, T, Stawski, P, Kaiser, M, Brun, R, Bringmann, G
Format: Journal article
Language:English
Published: American Chemical Society 2016