High resolution sequencing of hepatitis C virus reveals limited intra-hepatic compartmentalization in end stage liver disease

The high replication and mutation rate of hepatitis C virus (HCV) results in a heterogeneous population of viral sequences in vivo. HCV replicates in the liver and infected hepatocytes occur as foci surrounded by uninfected cells that may promote compartmentalization of viral variants. Given recent...

Полное описание

Библиографические подробности
Главные авторы: Hedegaard, D, Tully, D, Rowe, I, Reynolds, G, Bean, D, Hu, K, Davis, C, Wilhelm, A, Ogilvie, C, Power, K, Tarr, A, Kelly, D, Allen, T, Balfe, P, McKeating, J
Формат: Journal article
Язык:English
Опубликовано: Elsevier 2016