Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease

Obesity strongly increases the risk of cardiometabolic diseases, yet the underlying mediators of this relationship are not fully understood. Given that obesity strongly influences circulating protein levels, we investigated proteins mediating the effects of obesity on coronary artery disease, stroke...

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Main Authors: Yoshiji, S, Lu, T, Butler-Laporte, G, Carrasco-Zanini-Sanchez, J, Su, C, Chen, Y, Liang, K, Willett, JDS, Wang, S, Adra, D, Ilboudo, Y, Sasako, T, Koyama, S, Nakao, T, Forgetta, V, Farjoun, Y, Zeberg, H, Zhou, S, Marks-Hultström, M, Machiela, MJ, Kaalia, R, Dashti, H, Claussnitzer, M, Flannick, J
Format: Journal article
Language:English
Published: Nature Research 2025