Order through destruction: how ER-associated protein degradation contributes to organelle homeostasis

The endoplasmic reticulum (ER) is a large, dynamic, and multifunctional organelle. ER protein homeostasis is essential for the coordination of its diverse functions and depends on ER-associated protein degradation (ERAD). The latter process selects target proteins in the lumen and membrane of the ER...

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Bibliographic Details
Main Authors: Christianson, JC, Carvalho, P
Format: Journal article
Language:English
Published: EMBO Press 2022