An open label randomized controlled trial of tamoxifen combined with amphotericin B and fluconazole for cryptococcal meningitis

<strong>Background:</strong> Cryptococcal meningitis has high mortality. Flucytosine is a key treatment but is expensive and rarely available. The anticancer agent tamoxifen has synergistic anti-cryptococcal activity with amphotericin in vitro. It is off-patent, cheap, and widely availab...

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Main Authors: Ngan, NTT, Thanh Hoang Le, N, Vi Vi, NN, Van, NTT, Mai, NTH, Van Anh, D, Trieu, PH, Lan, NPH, Phu, NH, Chau, NVV, Lalloo, DG, Hope, W, Beardsley, J, White, NJ, Geskus, R, Thwaites, GE, Krysan, D, Tai, LTH, Kestelyn, E, Binh, TQ, Hung, LQ, Tung, NLN, Day, JN
Format: Journal article
Language:English
Published: eLife Sciences Publications 2021