Paradoxical effects of trichostatin A: inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA.

Trichostatin A (TSA), an inhibitor of histone deacetylase (HDAC), is widely used to study the role of histone acetylation in gene expression, since genes that use histone acetylation as a means of regulating expression may be up regulated when TSA is added. In this study, however, we show that TSA h...

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Bibliographic Details
Main Authors: Nair, A, Boersma, L, Schiltz, L, Chaudhry, M, Muschel, R, Chaudry, A
Format: Journal article
Language:English
Published: 2001