Functional significance of Na+/Ca2+ exchangers co−localization with ryanodine receptors

Co-localization of Na+/Ca2+ exchangers (NCX) with ryanodine receptors (RyRs) is debated. We incorporate local NCX current in a biophysically detailed model of L-type Ca2+ channels (LCCs) and RyRs and study the effect of NCX on the regulation of Ca2+ -induced Ca2+ release and the shape of the action...