DNA damage repair proteins as determinants of sensitivity to platinum chemotherapy
<p>DNA damage repair proteins are determinants of sensitivity to platinum chemotherapy in preclinical models and in patients with cancer. The XPF- ERCC1 heterodimer incises DNA strands adjacent to platinum-DNA adducts and is essential for repair of platinum-DNA interstrand cross-links (ICLs)....
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| Format: | Thesis |
| Language: | English |
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2016
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