Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons

Cohesin is a highly conserved multisubunit complex that holds sister chromatids together in mitotic cells. At the metaphase to anaphase transition, proteolytic cleavage of the α kleisin subunit (Rad21) by separase causes cohesin's dissociation from chromosomes and triggers sister-chromatid disj...

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Bibliographic Details
Main Authors: Pauli, A, Althoff, F, Oliveira, R, Heidmann, S, Schuldiner, O, Lehner, C, Dickson, B, Nasmyth, K
Format: Journal article
Language:English
Published: 2008