Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons
Cohesin is a highly conserved multisubunit complex that holds sister chromatids together in mitotic cells. At the metaphase to anaphase transition, proteolytic cleavage of the α kleisin subunit (Rad21) by separase causes cohesin's dissociation from chromosomes and triggers sister-chromatid disj...
Hauptverfasser: | Pauli, A, Althoff, F, Oliveira, R, Heidmann, S, Schuldiner, O, Lehner, C, Dickson, B, Nasmyth, K |
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Format: | Journal article |
Sprache: | English |
Veröffentlicht: |
2008
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